Evolutionary interplay between symbiotic relationships and patterns of signal peptide gain and loss

Hönigschmid, Peter and Bykova, Nadya and Schneider, René and Ivankov, Dmitrii and Frishman, Dmitrij (2018) Evolutionary interplay between symbiotic relationships and patterns of signal peptide gain and loss. Genome Biology and Evolution, 10 (3). 928 -938. ISSN 1759-6653

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Official URL: http://dx.doi.org/10.1093/gbe/evy049


Can orthologous proteins differ in terms of their ability to be secreted? To answer this question, we investigated the distribution of signal peptides within the orthologous groups of Enterobacterales. Parsimony analysis and sequence comparisons revealed a large number of signal peptide gain and loss events, in which signal peptides emerge or disappear in the course of evolution. Signal peptide losses prevail over gains, an effect which is especially pronounced in the transition from the free-living or commensal to the endosymbiotic lifestyle. The disproportionate decline in the number of signal peptide-containing proteins in endosymbionts cannot be explained by the overall reduction of their genomes. Signal peptides can be gained and lost either by acquisition/elimination of the corresponding N-terminal regions or by gradual accumulation of mutations. The evolutionary dynamics of signal peptides in bacterial proteins represents a powerful mechanism of functional diversification.

Item Type: Article
DOI: 10.1093/gbe/evy049
Uncontrolled Keywords: Sequence analysis, molecular evolution, comparative genomics, signal peptides
Subjects: 500 Science > 570 Life sciences; biology > 576 Genetics and evolution
Research Group: Kondrashov Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 11 Apr 2018 09:22
Last Modified: 11 Apr 2018 09:22
URI: https://repository.ist.ac.at/id/eprint/999

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