Mechanisms of radial glia progenitor cell lineage progression

Beattie, Robert and Hippenmeyer, Simon (2017) Mechanisms of radial glia progenitor cell lineage progression. FEBS letters, 591. 3993 -4008 . ISSN 1873-3468

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The mammalian cerebral cortex is responsible for higher cognitive functions such as perception, consciousness, and acquiring and processing information. The neocortex is organized into six distinct laminae, each composed of a rich diversity of cell types which assemble into highly complex cortical circuits. Radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an inaugural quantitative framework of RGP lineage progression. We further discuss the importance of the relative contribution of intrinsic gene functions and non-cell-autonomous or community effects in regulating RGP proliferation behavior and lineage progression.

Item Type: Article
DOI: 10.1002/1873-3468.12906
Uncontrolled Keywords: Neurogenesis, cerebral cortex, clonal analysis, mosaic analysis with double markers, neuroscience, gliogenesis, neurodevelopment, radialglia progenitor, single-cell labeling
Subjects: 500 Science > 570 Life sciences; biology > 571 Physiology
600 Technology > 610 Medicine and health
Research Group: Hippenmeyer Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 10 Jan 2018 08:54
Last Modified: 16 Jan 2018 07:57

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