Modern ionotropic glutamate receptor with a K+ selectivity signature sequence

Janovjak, Harald and Sandoz, Guillaume and Isacoff, Ehud Y (2011) Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications, 2 (232 ). pp. 1-6. ISSN 2041-1723

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Official URL: http://dx.doi.org/10.1038/ncomms1231

Abstract

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K+ channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors.

Item Type: Article
DOI: 10.1038/ncomms1231
Subjects: 500 Science > 570 Life sciences; biology
500 Science > 570 Life sciences; biology > 571 Physiology
Research Group: Janovjak Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 03 Jul 2017 13:33
Last Modified: 19 Sep 2017 15:10
URI: https://repository.ist.ac.at/id/eprint/832

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