Synaptic mechanisms of pattern completion in the hippocampal CA3 network

Guzman, Segundo J and Schlögl, Alois and Frotscher, Michael and Jonas, Peter (2016) Synaptic mechanisms of pattern completion in the hippocampal CA3 network. Science, 353 (6304). pp. 1117-1123. ISSN 0036-8075

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Official URL: http://dx.doi.org/10.1126/science.aaf1836

Abstract

The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording fromup to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion.Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.

Item Type: Article
DOI: 10.1126/science.aaf1836
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Jonas Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 30 May 2017 15:24
Last Modified: 04 Sep 2017 15:00
URI: https://repository.ist.ac.at/id/eprint/823

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