Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae

Sachdeva, Himani and Barma, Mustansir and Rao, Madan (2016) Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae. Scientific Reports, 6. Article number: 38840 . ISSN 2045-2322

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Official URL: http://dx.doi.org/10.1038/srep38840

Abstract

A central issue in cell biology is the physico-chemical basis of organelle biogenesis in intracellular trafficking pathways, its most impressive manifestation being the biogenesis of Golgi cisternae. At a basic level, such morphologically and chemically distinct compartments should arise from an interplay between the molecular transport and chemical maturation. Here, we formulate analytically tractable, minimalist models, that incorporate this interplay between transport and chemical progression in physical space, and explore the conditions for de novo biogenesis of distinct cisternae. We propose new quantitative measures that can discriminate between the various models of transport in a qualitative manner-this includes measures of the dynamics in steady state and the dynamical response to perturbations of the kind amenable to live-cell imaging.

Item Type: Article
DOI: 10.1038/srep38840
Subjects: 500 Science > 570 Life sciences; biology > 576 Genetics and evolution
Research Group: Barton Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 16 Jan 2017 13:52
Last Modified: 30 Aug 2017 07:58
URI: https://repository.ist.ac.at/id/eprint/737

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