Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

Vyleta, Nicholas P and Borges Merjane, Carolina and Jonas, Peter (2016) Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses. eLife. ISSN 2050-084X

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Official URL: http://dx.doi.org/10.7554/eLife.17977

Abstract

Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network.

Item Type: Article
DOI: 10.7554/eLife.17977
Subjects: 500 Science > 570 Life sciences; biology > 571 Physiology
500 Science > 570 Life sciences; biology > 572 Biochemistry
Research Group: Jonas Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 06 Dec 2016 14:12
Last Modified: 05 Sep 2017 09:56
URI: https://repository.ist.ac.at/id/eprint/715

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