Elevated virulence of an emerging viral genotype as a driver of honeybee loss

McMahon, Dino P and Natsopoulou, Myrsini E and Doublet, Vincent and Fürst, Matthias A and Weging, Silvio and Brown, Mark J and Gogol-Döring, Andreas and Paxton, Robert J (2016) Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society of London Series B Biological Sciences, 283 (1833). Article number: 20160811 . ISSN 0962-8452

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Official URL: http://dx.doi.org/10.1098/rspb.2016.0811

Abstract

Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.

Item Type: Article
DOI: 10.1098/rspb.2016.0811
Uncontrolled Keywords: virulence, Decline, Emerging infectious disease, Pollinator
Subjects: 500 Science > 570 Life sciences; biology > 576 Genetics and evolution
500 Science > 590 Animals (zoology) > 592 Invertebrates
Research Group: Cremer Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 05 Dec 2016 15:38
Last Modified: 05 Sep 2017 09:28
URI: https://repository.ist.ac.at/id/eprint/701

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