Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus

Kovács, Krisztián A and O'Neill, Joseph and Schönenberger, Philipp and Penttonen, Markku and Rangel Guerrero, Dámaris K and Csicsvári, József (2016) Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One, 11 (10). Article number: e0164675 . ISSN 1932-6203

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Official URL: http://dx.doi.org/10.1371/journal.pone.0164675

Abstract

During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity- related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during the sleep/rest session after the first exploration of a novel environment are needed for the stabilization of the CA1 code, which process requires plasticity. We found that the newly-formed representation in the CA1 has the same level of stability with optogenetic SWR blockade as with a control manipulation that delivered the same amount of light into the brain. Therefore our results suggest that at least in the case of passive exploratory behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles.

Item Type: Article
DOI: 10.1371/journal.pone.0164675
Uncontrolled Keywords: Rest, Sleep, Exploratory Behavior, plasticity, hippocampal CA1 region, spatial learning
Subjects: 500 Science > 570 Life sciences; biology
500 Science > 570 Life sciences; biology > 571 Physiology
Research Group: Csicsvari Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 05 Dec 2016 14:45
Last Modified: 05 Sep 2017 09:15
URI: https://repository.ist.ac.at/id/eprint/690

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