Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments

Chait, Remy and Palmer,, Adam C and Yelin, Idan and Kishony, Roy (2016) Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. Nature Communications, 7. Article number: 10333 . ISSN 2041-1723

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Official URL: http://dx.doi.org/10.1038/ncomms10333

Abstract

Antibiotic-sensitive and -resistant bacteria coexist in natural environments with low, if detectable, antibiotic concentrations. Except possibly around localized antibiotic sources, where resistance can provide a strong advantage, bacterial fitness is dominated by stresses unaffected by resistance to the antibiotic. How do such mixed and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resistance? Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetracycline resistance around localized sources of almost any toxin or stress. Furthermore, certain stresses generate alternating rings of selection for and against resistance around a localized source of the antibiotic. In these conditions, localized antibiotic sources, even at high strengths, can actually produce a net selection against resistance to the antibiotic. Our results show that interactions between the effects of an antibiotic and other stresses in inhomogeneous environments can generate pervasive, complex patterns of selection both for and against antibiotic resistance.

Item Type: Article
DOI: 10.1038/ncomms10333
Uncontrolled Keywords: nonhuman, article, fitness, inhibition, Bacteria (microorganisms), chloramphenicol, ciprofloxacin, doxycycline, rifampicin, cefoxitin, cotrimoxazole, nitrofurantoin, spectinomycin, spiramycin, tetracycline, tigecycline, tobramycin, bacterium, environmental stress, toxin, sensitivity, drug potentiation, physical stress, cefoxitin, 33564-30-6, 35607-66-0, chloramphenicol, 134-90-7, 2787-09-9, 56-75-7, ciprofloxacin, 85721-33-1, cotrimoxazole, 8064-90-2, doxycycline, 10592-13-9, 17086-28-1, 564-25-0, 94088-85-4, nitrofurantoin, 54-87-5, 67-20-9, rifampicin, 13292-46-1, spectinomycin, 1695-77-8, 21736-83-4, 23312-56-3, spiramycin, 8025-81-8, tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1, tigecycline, 220620-09-7, tobramycin, 32986-56-4
Subjects: 500 Science > 570 Life sciences; biology
500 Science > 570 Life sciences; biology > 579 Microorganisms, fungi, algae
Research Group: Guet Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 10 Nov 2016 08:04
Last Modified: 30 Aug 2017 14:34
URI: https://repository.ist.ac.at/id/eprint/662

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