Activity dependent plasticity of hippocampal place maps

Schoenenberger, Philipp and O'Neill, Joseph and Csicsvári, József (2016) Activity dependent plasticity of hippocampal place maps. Nature Communications, 7. Article number: 11824 . ISSN 2041-1723

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Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through activity-dependent synaptic plasticity. Here we examine how changes in activity influence spatial coding in rats using halorhodopsin-mediated, spatially selective optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression in many place cells and interneurons; some place cells increase their firing through disinhibition, whereas some show no effect. We find that place fields of the unaffected subpopulation remain stable. On the other hand, place fields of suppressed place cells were unstable, showing remapping across sessions before and after optogenetic inhibition. Disinhibited place cells had stable maps but sustained an elevated firing rate. These findings suggest that place representation in the hippocampus is constantly governed by activity-dependent processes, and that disinhibition may provide a mechanism for rate remapping.

Item Type: Article
DOI: 10.1038/ncomms11824
Uncontrolled Keywords: Hippocampus, Synaptic plasticity, Rattus
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Csicsvari Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 09 Nov 2016 15:30
Last Modified: 05 Sep 2017 09:48

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