Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

Mishra, Rajiv K and Kim, Sooyun and Guzman, Segundo J and Jonas, Peter (2016) Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks. Nature Communications, 7. Article Number: 11552 . ISSN 2041-1723

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Abstract

CA3–CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these synapses are consistent with their proposed network functions remains unclear. Here, we examine the properties of spike timing-dependent plasticity (STDP) at CA3–CA3 synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs) and action potentials (APs) induces long-term potentiation (LTP), independent of temporal order. The STDP curve is symmetric and broad (half-width ~150 ms). Consistent with these STDP induction properties, AP–EPSP sequences lead to supralinear summation of spine [Ca2+] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and EPSPs summate with dendritic ADPs. In autoassociative network models, storage and recall are more robust with symmetric than with asymmetric STDP rules. Thus, a specialized STDP induction rule allows reliable storage and recall of information in the hippocampal CA3 network.

Item Type: Article
DOI: 10.1038/NCOMMS11552
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Jonas Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 25 May 2016 13:36
Last Modified: 05 Sep 2017 09:32
URI: https://repository.ist.ac.at/id/eprint/582

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