Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

Chabaud, Mélanie and Heuzé, Mélina L and Bretou, Marine and Vargas , P and Maiuri, Paolo and Solanes, Paola and Maurin, Mathieu and Terriac, Emmanuel and Le Berre, Maël and Lankar, Danielle and Piolot, Tristan and Adelstein, Robert S and Zhang, Yingfan and Sixt, Michael and Jacobelli, Jordan and Bénichou, Olivier J and Voituriez, Raphaél and Piel, Matthieu and Lennon-Duménil, Ana M (2015) Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nature Communications, 6. Article No. 7526. ISSN 2041-1723

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Abstract

The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.

Item Type: Article
DOI: 10.1038/ncomms8526
Uncontrolled Keywords: Antigen Presentation, cell function, cell migration, controlled study, Locomotion, Endosome, Pinocytosis, regulatory mechanism, dendritic cell, protein, cell motility, Mobility, major histocompatibility antigen class 2, myosin IIA, antigen, germ cell, antigen function, endolysosome, extracellular fluid, lysosome, macropinosome
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Sixt Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 25 Jan 2016 16:08
Last Modified: 30 Aug 2017 09:15
URI: https://repository.ist.ac.at/id/eprint/476

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