Morpho-physiological criteria divide dentate gyrus interneurons into classes

Hosp, Jonas A and Strüber, Michael and Yanagawa, Yuchio and Obata, Kunihiko and Vida, Imre and Jonas, Peter and Bartos, Marlene (2014) Morpho-physiological criteria divide dentate gyrus interneurons into classes. Hippocampus, 23 (2). pp. 189-203. ISSN 1098-1063

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Abstract

GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets. Indeed, interneurons display a high degree of morphological and physiological heterogeneity. However, whether their morphological and physiological characteristics are correlated and whether interneuron diversity can be described by a continuum of GABAergic cell types or by distinct classes has remained unclear. Here we perform a detailed morphological and physiological characterization of GABAergic cells in the dentate gyrus, the input region of the hippocampus. To achieve an unbiased and efficient sampling and classification we used knock-in mice expressing the enhanced green fluorescent protein (eGFP) in glutamate decarboxylase 67 (GAD67)-positive neurons and performed cluster analysis. We identified five interneuron classes, each of them characterized by a distinct set of anatomical and physiological parameters. Cross-correlation analysis further revealed a direct relation between morphological and physiological properties indicating that dentate gyrus interneurons fall into functionally distinct classes which may differentially control neuronal network activity.

Item Type: Article
DOI: 10.1002/hipo.22214
Uncontrolled Keywords: dentate gyrus, classification, basket cell, dendrite-inhibiting interneuron, GAD67-GFP
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Jonas Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 07 Jan 2016 14:27
Last Modified: 05 Sep 2017 14:52
URI: https://repository.ist.ac.at/id/eprint/461

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