Low-dose sevoflurane promoteshippocampal neurogenesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats

Chen, Chong and Wang, Chao and Zhao, Xuan and Zhou, Tao and Xu, Dao-Jie and Wang, Zhi-Ru and Wang, Ying-Wei (2015) Low-dose sevoflurane promoteshippocampal neurogenesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats. ASN Neuro, 7 (2). ISSN 1759-0914

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Abstract

Huge body of evidences demonstrated that volatile anesthetics affect the hippocampal neurogenesis and neurocognitive functions, and most of them showed impairment at anesthetic dose. Here, we investigated the effect of low dose (1.8%) sevoflurane on hippocampal neurogenesis and dentate gyrus-dependent learning. Neonatal rats at postnatal day 4 to 6 (P4-6) were treated with 1.8% sevoflurane for 6 hours. Neurogenesis was quantified by bromodeoxyuridine labeling and electrophysiology recording. Four and seven weeks after treatment, the Morris water maze and contextual-fear discrimination learning tests were performed to determine the influence on spatial learning and pattern separation. A 6-hour treatment with 1.8% sevoflurane promoted hippocampal neurogenesis and increased the survival of newborn cells and the proportion of immature granular cells in the dentate gyrus of neonatal rats. Sevoflurane-treated rats performed better during the training days of the Morris water maze test and in contextual-fear discrimination learning test. These results suggest that a subanesthetic dose of sevoflurane promotes hippocampal neurogenesis in neonatal rats and facilitates their performance in dentate gyrus-dependent learning tasks.

Item Type: Article
DOI: 10.1177/1759091415575845
Uncontrolled Keywords: Neurogenesis, dentate gyrus, neonate, pattern separation, sevoflurane, spatial learning
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Jonas Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 07 Jan 2016 13:24
Last Modified: 05 Sep 2017 10:18
URI: https://repository.ist.ac.at/id/eprint/456

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