Transformation of stimulus correlations by the retina

Simmons, Kristina D and Prentice, Jason S and Tkačik, Gašper and Homann, Jan and Yee, Heather K and Palmer, Stephanie E and Nelson, Philip C and Balasubramanian, Vijay (2013) Transformation of stimulus correlations by the retina. PLoS Computational Biology, 9 (12). Article No. e1003344. ISSN 1553-7358

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Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible.

Item Type: Article
DOI: 10.1371/journal.pcbi.1003344
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Tkacik Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 04 Jan 2016 15:46
Last Modified: 05 Sep 2017 14:37

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