Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome

Arque, Gloria and Casanovas, Anna and Dierssen, Mara (2013) Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. PLoS One, 8 (1). Article No. e54285. ISSN 1932-6203

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Abstract

Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor development of infants and young children. DYRK1A, a candidate gene for DS abnormalities has been implicated in motor function due to its expression in motor nuclei in the adult brain, and its overexpression in DS mouse models leads to hyperactivity and altered motor learning. However, its precise role in the adult motor system, or its possible involvement in postnatal locomotor development has not yet been clarified. During the postnatal period we observed time-specific expression of Dyrk1A in discrete subsets of brainstem nuclei and spinal cord motor neurons. Interestingly, we describe for the first time the presence of Dyrk1A in the presynaptic terminal of the neuromuscular junctions and its axonal transport from the facial nucleus, suggesting a function for Dyrk1A in these structures. Relevant to DS, Dyrk1A overexpression in transgenic mice (TgDyrk1A) produces motor developmental alterations possibly contributing to DS motor phenotypes and modifies the numbers of motor cholinergic neurons, suggesting that the kinase may have a role in the development of the brainstem and spinal cord motor system.

Item Type: Article
DOI: 10.1371/journal.pone.0054285
Uncontrolled Keywords: Down syndrome, DYRK1A gene
Subjects: 500 Science > 570 Life sciences; biology
Research Group: Hippenmeyer Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 04 Jan 2016 15:01
Last Modified: 30 Aug 2017 11:53
URI: https://repository.ist.ac.at/id/eprint/407

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