Tread lightly interpreting polygenic tests of selection

Novembre, John and Barton, Nicholas H (2018) Tread lightly interpreting polygenic tests of selection. Genetics, 208 (4). pp. 1351-1355. ISSN 0016-6731

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In this issue of GENETICS, a new method for detecting natural selection on polygenic traits is developed and applied to sev- eral human examples ( Racimo et al. 2018 ). By de fi nition, many loci contribute to variation in polygenic traits, and a challenge for evolutionary ge neticists has been that these traits can evolve by small, nearly undetectable shifts in allele frequencies across each of many, typically unknown, loci. Recently, a helpful remedy has arisen. Genome-wide associ- ation studies (GWAS) have been illuminating sets of loci that can be interrogated jointly for c hanges in allele frequencies. By aggregating small signal s of change across many such loci, directional natural selection is now in principle detect- able using genetic data, even for highly polygenic traits. This is an exciting arena of progress – with these methods, tests can be made for selection associated with traits, and we can now study selection in what may be its most prevalent mode. The continuing fast pace of GWAS publications suggest there will be many more polygenic tests of selection in the near future, as every new GWAS is an opportunity for an accom- panying test of polygenic selection. However, it is important to be aware of complications th at arise in interpretation, especially given that these studies may easily be misinter- preted both in and outside the evolutionary genetics commu- nity. Here, we provide context for understanding polygenic tests and urge caution regarding how these results are inter- preted and reported upon more broadly.

Item Type: Article
DOI: 10.1534/genetics.118.300786
Subjects: 500 Science > 570 Life sciences; biology > 576 Genetics and evolution
Research Group: Barton Group
SWORD Depositor: Sword Import User
Depositing User: Sword Import User
Date Deposited: 19 Apr 2018 09:36
Last Modified: 19 Apr 2018 09:36

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